Mucosal-associated invariant T cells augment immunopathology and gastritis in chronic helicobacter pylori infection

C D'Souza; T Pediongco; H Wang; JPY Scheerlinck; L Kostenko; R Esterbauer; AW Stent; SBG Eckle; BS Meehan; RA Strugnell; H Cao; L Liu; JYW Mak; G Lovrecz; L Lu; DP Fairlie; J Rossjohn; J McCluskey; AL Every; Z Chen; AJ Corbett

Journal article

Mucosal-associated invariant T cells augment immunopathology and gastritis in chronic helicobacter pylori infection

C D'Souza, T Pediongco, H Wang, JPY Scheerlinck, L Kostenko, R Esterbauer, AW Stent, SBG Eckle, BS Meehan, RA Strugnell, H Cao, L Liu, JYW Mak, G Lovrecz, L Lu, DP Fairlie, J Rossjohn, J McCluskey, AL Every, Z Chen Show all

Journal of Immunology | AMER ASSOC IMMUNOLOGISTS | Published : 2018

DOI: 10.4049/jimmunol.1701512

Abstract

Mucosal-associated invariant T (MAIT) cells produce inflammatory cytokines and cytotoxic granzymes in response to by-products of microbial riboflavin synthesis. Although MAIT cells are protective against some pathogens, we reasoned that they might contribute to pathology in chronic bacterial infection. We observed MAIT cells in proximity to Helicobacter pylori bacteria in human gastric tissue, and so, using MR1-tetramers, we examined whether MAIT cells contribute to chronic gastritis in a mouse H. pylori SS1 infection model. Following infection, MAIT cells accumulated to high numbers in the gastric mucosa of wild-type C57BL/6 mice, and this was even more pronounced in MAIT TCR transgenic mic..

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University of Melbourne Researchers

Robyn Esterbauer Author

Andrew Stent Author

Sidonia Eckle Author

Bronwyn Meehan Author

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Grants

Funding Acknowledgements

This work was supported by Program Grants 1016629 and 1113293 and Project Grants 1062889, 1125493, and 1120467 from the National Health and Medical Research Council of Australia and by a Merieux Research Grant. A.J.C. is supported by an Australian Research Council Future Fellowship. J.R. is supported by an Australian Research Council Laureate Fellowship. D.P.F. is supported by a National Health and Medical Research Council Senior Principal Research Fellowship. S.B.G.E. is supported by an Australian Research Council Discovery Early Career Researcher Award Fellowship. C.D. was supported by a Melbourne International Research Scholarship and a Melbourne International Fee Remission Scholarship from The University of Melbourne. H.W. is supported by a Melbourne International Engagement Award from The University of Melbourne.